8-sulfo-3-quinoline carboxylic acids and process therefore

Details 8-sulfo-3-quinoline carboxylic acids and process therefore 8-sulfo-3-quinoline carboxylic acids and process therefore

1994-08-10

1995-11-14

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D215233

Patent

active

054668085

ABSTRACT:
This invention is a process for preparing 8-sulfo-7-chloro-6-fluoro-4-oxo-1,4-dihydro-3-quinolinic acid wherein the amino analinomethylenomalonate starting material of Formula 1 is unsubstituted at the R.sub.1 and R.sub.2 positions i.e. these moieties are hydrogen. In the ring closing process when R.sub.1 and R.sub.2 are hydrogen, not only does the ring close but the ring position at R.sub.2 is sulfonated.

REFERENCES:
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patent: 3673193 (1972-06-01), Lesher et al.
patent: 4528287 (1985-07-01), Itoh et al.
Hui-Yuan et al, Pharmaceutical Industry, 1986, pp. 390-394.
Bridges et al. J. Heterocyclic Chem, vol. 27, 1990, pp. 1527-1536.

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