8-substituted purines as selective adenosine receptor agents

Details 8-substituted purines as selective adenosine receptor agents 8-substituted purines as selective adenosine receptor agents

1991-03-12

1993-05-04

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514262, 544266, 544267, C07D47301, A61K 3152

Patent

active

052082407

ABSTRACT:
The present invention relates to certain novel 8-substituted purines as selective A.sub.1 -adenosine receptor antagonists which are useful in the treatment of patients suffering from Alzheimer's disease, congestive heart failure or pulmonary bronchoconstriction.

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Peet et al., "A Novel Synthesis of Xanthines: Support for a New Binding Mode for Xanthines with Respect to Adenosine at Adenosine Receptors", J. Med. Chem. 33, 3127-3130, (1990).

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