8-Substituted cyclic nucleotides by free radical alkylation and

Details 8-Substituted cyclic nucleotides by free radical alkylation and 8-Substituted cyclic nucleotides by free radical alkylation and

1974-12-20

1976-07-06

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424180, C07C 1920

Patent

active

039681017

ABSTRACT:
Novel compounds of the general formula ##SPC1##
Wherein X is H or NH.sub.2 ; R' is C.sub.1 to C.sub.8 alkyl, C.sub.1 to C.sub.8 substituted alkyl, benzyl, C.sub.1 to C.sub.8 acyl, benzoyl, carbamoyl, are disclosed as well as a novel free radial alkylation and acylation process for making such compounds. The compounds of the invention display activity comparable to or superior to their naturally occurring analogue while resisting phosphodiesterase degradation. In some cases the compounds of this invention actually inhibit enzymatic degradation of the natural analogue.

REFERENCES:
kawazoe et al. "Chem. Pharm. Bull" vol. 20, pp. 1341-1342, 1972.

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