Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1993-03-18
1997-06-03
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514427, 514429, 514438, 514461, 5142265, 514255, 514278, 514319, 514326, 514328, 514412, 514414, 514415, 544 33, 544392, 546 16, 546 19, 546205, 546206, 546207, 546208, 546212, 546213, 546214, 548517, 548525, 548465, 5483647, 5483641, 5483657, 5483651, 5483615, 5483625, 5483061, 5483051, 5483121, 5483147, 549 80, 549504, 564374, 564428, A61K 31135, C07C22520, C07D30752, C07D33304
Patent
active
056355378
ABSTRACT:
A compound of the formula ##STR1## Z is hydrogen or halogen, Q is COR.sup.1 or 5-or 6-membered aryl which may contain 1 or 2 heteroatoms selected from N, 0 or S and may be substituted or fused wherein R is hydrogen or C.sub.1 -methyl (cis-configuration), R.sup.1 is C.sub.1 -C.sub.6 alkyl or an aromatic ring which may contain heteroatoms selected from O and S and may be substituted or fused to an optionally substituted benzene ring, R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sup.3 may be different groups defined in claim 1, and enantiomers/salts thereof, processes for preparation of said compounds, pharmaceutical preparations containing said compounds, use of and method of treatment of disorders in CNS by using said compounds.
REFERENCES:
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Hammon et al. "The central 5HT1A receptors:pharmacological, biochemical, functional, and regulatory properties" N. Y. Aca. Scien. v. 600, p. 114-131 1990.
Gotto et al "The Role of Receptors in Biology & Medicine" Raven Press, p. 191 (1986).
Glennon "Central Serotomine Receptors as targets for dry research" J. Med. Chem. 30 1-12 (1987).
Aridsson et al "5-hydroxtryptamine receptors Agonists" J. Med. Chem. 27 45-51 (1984).
Anden Nils-Erik
Backlund Hook Berit C. E.
Bjork Anna L.
Hacksell Uli A.
Hillver Sven-Erik
Astra Aktiebolag
Chang Ceila
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