8-substituted-2-aminotetralins

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514427, 514429, 514438, 514461, 5142265, 514255, 514278, 514319, 514326, 514328, 514412, 514414, 514415, 544 33, 544392, 546 16, 546 19, 546205, 546206, 546207, 546208, 546212, 546213, 546214, 548517, 548525, 548465, 5483647, 5483641, 5483657, 5483651, 5483615, 5483625, 5483061, 5483051, 5483121, 5483147, 549 80, 549504, 564374, 564428, A61K 31135, C07C22520, C07D30752, C07D33304

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active

056355378

ABSTRACT:
A compound of the formula ##STR1## Z is hydrogen or halogen, Q is COR.sup.1 or 5-or 6-membered aryl which may contain 1 or 2 heteroatoms selected from N, 0 or S and may be substituted or fused wherein R is hydrogen or C.sub.1 -methyl (cis-configuration), R.sup.1 is C.sub.1 -C.sub.6 alkyl or an aromatic ring which may contain heteroatoms selected from O and S and may be substituted or fused to an optionally substituted benzene ring, R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sup.3 may be different groups defined in claim 1, and enantiomers/salts thereof, processes for preparation of said compounds, pharmaceutical preparations containing said compounds, use of and method of treatment of disorders in CNS by using said compounds.

REFERENCES:
patent: 4876284 (1989-10-01), Arvidsson et al.
Peroutka, S.J. "Pharmacological Differentiation and Characterization of 5-HT.sub.1A' 5-HT.sub.1B' and 5-HT.sub.1C Binging Sites in Rat Frontal Cortex", J. Neurochem., 47: 529-540, 1986.
Hammon et al. "The central 5HT1A receptors:pharmacological, biochemical, functional, and regulatory properties" N. Y. Aca. Scien. v. 600, p. 114-131 1990.
Gotto et al "The Role of Receptors in Biology & Medicine" Raven Press, p. 191 (1986).
Glennon "Central Serotomine Receptors as targets for dry research" J. Med. Chem. 30 1-12 (1987).
Aridsson et al "5-hydroxtryptamine receptors Agonists" J. Med. Chem. 27 45-51 (1984).

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