8-quinolinxanthine and 8-isoquinolinxanthine derivatives as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S268000

Reexamination Certificate

active

11329889

ABSTRACT:
A compound of formula (I)R1is hydrogen or alkyl optionally substituted by hydroxy, alkoxy, or alkylthio, R2is hydrogen, alkyl, hydroxyalkyl, alkylcarbonyloxyalkyl, alkoxyalkyl, alkylthioalkyl, alkenyl, cycloalkylalkyl, heterocyclylalkyl, aralkyl in which the aryl ring thereof is optionally fused to a 5-membered heterocyclic group or is optionally substituted by one or more substituents selected from alkoxy, amino, alkylamino, dialkylamino, acylamino, halogen, hydroxy, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, alkylsufonylamino or dialkylaminosulfonylamino, R3is hydrogen or alkyl optionally substituted by hydroxy, alkoxy, or alkylthio, R4is hydrogen or alkyl, R5is a quinolinyl, isoquinolinyl or oxodihydroisoquinolinyl group optionally fused to a 5-membered heterocyclic group and optionally substituted by one or more substituents selected from halogen, cyano, hydroxy, alkyl, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkoxy, alkylthio, alkenyl, alkoxycarbonyl, alkynyl, carboxyl, acyl, a group of formula —N(R6)R7, aryl optionally substituted by one or more substituents selected from halogen or alkoxy, or heteroaryl having 5 or 6 ring atoms attached through a ring carbon atom to the indicated carbon atom, and R6and R7are each independently hydrogen or alkyl optionally substituted by hydroxy or alkoxy or one of R6and R7is hydrogen and the other is acyl, or R6and R7together with the nitrogen atom to which they are attached denote a 5- or 66-mambered heterocyclyl group.

REFERENCES:
patent: 2879271 (1959-03-01), Kalischnigg
patent: 4599338 (1986-07-01), Regnier et al.
patent: WO 94/28902 (1994-12-01), None
patent: WO 99/62905 (1999-12-01), None
patent: WO 00/37061 (2000-06-01), None

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