Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-07-19
2005-07-19
Solola, Taofiq (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S118000, C544S268000
Reexamination Certificate
active
06919337
ABSTRACT:
A compound of formula (I)R1is hydrogen or alkyl optionally substituted by hydroxy, alkoxy, or alkylthio, R2is hydrogen, alkyl, hydroxyalkyl, alkylcarbonyloxyalkyl, alkoxyalkyl, alkylthioalkyl, alkenyl, cycloalkylalkyl, heterocyclylalkyl, aralkyl in which the aryl ring thereof is optionally fused to a 5-membered heterocyclic group or is optionally substituted by one or more substituents selected from alkoxy, amino, alkylamino, dialkylamino, acylamino, halogen, hydroxy, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino or dialkylaminosulfonylamino, R3is hydrogen or alkyl optionally substituted by hydroxy, alkoxy, or alkylthio, R4is hydrogen or alkyl, R5is a quinolinyl, isoquinolinyl or oxodihydroisoquinolinyl group optionally fused to a 5-membered heterocyclic group and optionally substituted by one or more substituents selected from halogen, cyano, hydroxy, alkyl, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkoxy, alkylthio, alkenyl, alkoxycarbonyl, alkynyl, carboxyl, acyl, a group of formula —N(R6)R7, aryl optionally substituted by one or more substituents selected from halogen or alkoxy, or heteroaryl having 5 or 6 ring atoms attached through a ring carbon atom to the indicated carbon atom, and R6and R7are each independently hydrogen or alkyl optionally substituted by hydroxy or alkoxy or one of R6and R7is hydrogen and the other is acyl, or R6and R7together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclyl group.
REFERENCES:
patent: 4599338 (1986-07-01), Regnier et al.
patent: 94/28904 (1994-12-01), None
patent: 99/62905 (1999-12-01), None
patent: 00/37061 (2000-06-01), None
Bhalay Gurdip
Collingwood Stephen Paul
Fairhurst Robin Alec
Gomez Sylvie Felicite
Naef Ret
Houghton Gregory C.
Novartis AG
Solola Taofiq
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