Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1986-07-14
1987-06-23
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
546 67, 546 69, C07D45702, C07D45706, A61K 3148
Patent
active
046754040
ABSTRACT:
Ergoline derivatives of formula: ##STR1## wherein n=0,1,2; R.sub.1 =H, CH.sub.3 ; R.sub.2 =H, CH.sub.3, halogen; R.sub.3 =H, OCH.sub.3 ; R.sub.4 =hydrocarbon group and R.sub.5 is a residue of general formula II, III, IV, V, VI, VII: ##STR2## wherein R.sub.6 =H, Cl, OCH.sub.3, NR.sub.11 R.sub.12, wherein R.sub.11 and R.sub.12 =H, lower alkyl; phenyl or are bonded together to form a heterocyclic ring, R.sub.7, R.sub.8 and R.sub.9 and R.sub.10 =H or C.sub.1 -C.sub.3 alkyl, with the proviso that if R.sub.5 is of formula II and R.sub.2 =R.sub.7 =R.sub.8 =H, then R.sub.4 is not methyl or n is not 0.
Pharmaceutically acceptable acid addition salts are also provided. A method for their preparation is also provided.
The compounds have anti-depressive, anti-hypertensive and antiprolactin activity.
REFERENCES:
patent: 3228939 (1966-01-01), Bernardi et al.
patent: 3238211 (1966-03-01), Camerino et al.
patent: 3880856 (1975-04-01), Bach et al.
patent: 3904634 (1975-09-01), Arcari et al.
patent: 3920664 (1975-11-01), Clemens et al.
patent: 4035501 (1977-07-01), Hauth
patent: 4101552 (1978-07-01), Karacsony et al.
patent: 4166911 (1979-09-01), Bernardi et al.
patent: 4182883 (1980-01-01), Beran et al.
patent: 4526892 (1985-07-01), Salvati et al.
Berde and Schild, Ergot Alkaloids and Related Compounds, Springer-Verlag, New York, 1978.
Bernardi Luigi
Bosisio Germano
Eccel Rosanna
Rossi Alessandro
Salvati Patricia
Daus Donald G.
Farmitala Carlo Erba S.p.A.
Hendricks G.
LandOfFree
8-pyridazinylcarbamoyl ergolines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 8-pyridazinylcarbamoyl ergolines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 8-pyridazinylcarbamoyl ergolines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-722209