8-pyridazinylcarbamoyl ergolines

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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546 67, 546 69, C07D45702, C07D45706, A61K 3148

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active

046754040

ABSTRACT:
Ergoline derivatives of formula: ##STR1## wherein n=0,1,2; R.sub.1 =H, CH.sub.3 ; R.sub.2 =H, CH.sub.3, halogen; R.sub.3 =H, OCH.sub.3 ; R.sub.4 =hydrocarbon group and R.sub.5 is a residue of general formula II, III, IV, V, VI, VII: ##STR2## wherein R.sub.6 =H, Cl, OCH.sub.3, NR.sub.11 R.sub.12, wherein R.sub.11 and R.sub.12 =H, lower alkyl; phenyl or are bonded together to form a heterocyclic ring, R.sub.7, R.sub.8 and R.sub.9 and R.sub.10 =H or C.sub.1 -C.sub.3 alkyl, with the proviso that if R.sub.5 is of formula II and R.sub.2 =R.sub.7 =R.sub.8 =H, then R.sub.4 is not methyl or n is not 0.
Pharmaceutically acceptable acid addition salts are also provided. A method for their preparation is also provided.
The compounds have anti-depressive, anti-hypertensive and antiprolactin activity.

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patent: 4526892 (1985-07-01), Salvati et al.
Berde and Schild, Ergot Alkaloids and Related Compounds, Springer-Verlag, New York, 1978.

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