8-Piperazinyl-1,7-naphthyridine derivative having pharmaceutical

Details 8-Piperazinyl-1,7-naphthyridine derivative having pharmaceutical 8-Piperazinyl-1,7-naphthyridine derivative having pharmaceutical

1987-08-13

1989-09-12

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

514254, C07D47106, C07D40114, A61K 31475

Patent

active

048661767

ABSTRACT:
A 8-piperazinyl-1,7-naphthyridine derivative represented by the following formula (I): ##STR1## in which R represents a hydrogen atom, formyl group, acyl group, aroyl group, heteroaroyl group, substituted phenyl group, pyridyl group, aralkyl group or substituted or unsubstituted benzenesulfonyl group; and an acid adduct salt thereof. The compound has excellent antiinflammatory, antiarrhythmic and cardiotonic effects, and thus is useful as an antiinflammatory drug and a medicine for circulatory organs.

REFERENCES:
patent: 3429887 (1969-02-01), Lesher
patent: 3928367 (1975-12-01), Mayer et al.
patent: 4168311 (1979-09-01), Studeneer et al.
patent: 4176183 (1979-11-01), Baldwin et al.
patent: 4659710 (1987-04-01), Sato et al.
patent: 4690924 (1987-09-01), Sato et al.
patent: 4716170 (1987-12-01), Lesher et al.
"The Japanese Journal of Pharmacology", published by The Japanese Pharmacological Society; Mar. 29-Apr. 1, 1987; vol. 43, Summary of Discussions.
"A New Synthesis of 1,7-Naphthyridine", by Rosita Tan et al., Tetrahedron Letters, No. 12, pp. 1233-1237, Pergamon Press Ltd.
Studeneer et al., CA83-114227 y (1975) "N,N-Dialkylamino-Carbamic Acid Esters of Substituted Hydroxypyridine Derivatives".
Baldwin et al., CA 90-54931 f (1979) Naphthyridines.

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