8-(piperazin-1yl)- and 8-([1,4]diazepan-1yl)-xanthines, the...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S234200, C514S263200, C514S263210, C514S263220, C514S263340, C544S118000, C544S268000, C544S270000, C544S272000, C540S575000

Reexamination Certificate

active

07550455

ABSTRACT:
The present invention relates to substituted xanthines of the general formulain which R1to R3and n are as defined in claims1to8,their tautomers, their enantiomers, their diastereomers, their mixtures, their prodrugs and their salts, which have valuable pharmacological properties, in particular an inhibitory action on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

REFERENCES:
patent: 2928833 (1960-03-01), Leake et al.
patent: 4005208 (1977-01-01), Bender
patent: 4599338 (1986-07-01), Regnier et al.
patent: 5041448 (1991-08-01), Janssens
patent: 5051517 (1991-09-01), Findeisen
patent: 5223499 (1993-06-01), Greenlee
patent: 5234897 (1993-08-01), Findeisen et al.
patent: 5258380 (1993-11-01), Janssens
patent: 5266555 (1993-11-01), Findeisen et al.
patent: 5389642 (1995-02-01), Dorsch
patent: 5470579 (1995-11-01), Bonte et al.
patent: 5719279 (1998-02-01), Kuefner-Muhl et al.
patent: 5753635 (1998-05-01), Buckman
patent: 6303661 (2001-10-01), Demuth
patent: 6342601 (2002-01-01), Bantick
patent: 6548481 (2003-04-01), Demuth et al.
patent: 6579868 (2003-06-01), Asano
patent: 6784195 (2004-08-01), Hale et al.
patent: 6821978 (2004-11-01), Chackalamannil
patent: 6869947 (2005-03-01), Kanstrup
patent: 7060722 (2006-06-01), Kitajima
patent: 7074794 (2006-07-01), Kitajima
patent: 7074798 (2006-07-01), Yoshikawa
patent: 7074923 (2006-07-01), Dahanukar
patent: 7109192 (2006-09-01), Hauel
patent: 7179809 (2007-02-01), Eckhardt
patent: 7183280 (2007-02-01), Himmelsbach
patent: 7192952 (2007-03-01), Kanstrup
patent: 7217711 (2007-05-01), Eckhardt
patent: 7235538 (2007-06-01), Kanstrup et al.
patent: 2002/0161001 (2002-10-01), Kanstrup
patent: 2002/0169174 (2002-11-01), Chackalamannil et al.
patent: 2002/0198205 (2002-12-01), Himmelsbach et al.
patent: 2003/0105077 (2003-06-01), Kanstrup et al.
patent: 2003/0199528 (2003-10-01), Kanstrup
patent: 2003/0232987 (2003-12-01), Dahanukar et al.
patent: 2003/0236272 (2003-12-01), Carr
patent: 2004/0034014 (2004-02-01), Kanstrup et al.
patent: 2004/0077645 (2004-04-01), Himmelsbach et al.
patent: 2004/0082570 (2004-04-01), Yoshikawa et al.
patent: 2004/0087587 (2004-05-01), Himmelsbach
patent: 2004/0097510 (2004-05-01), Himmelsbach et al.
patent: 2004/0116328 (2004-06-01), Yoshikawa et al.
patent: 2004/0122228 (2004-06-01), Maier
patent: 2004/0138214 (2004-07-01), Himmelsbach et al.
patent: 2004/0138215 (2004-07-01), Eckhardt
patent: 2004/0166125 (2004-08-01), Himmelsbach
patent: 2005/0020574 (2005-01-01), Hauel et al.
patent: 2005/0026921 (2005-02-01), Eckhardt
patent: 2005/0130985 (2005-06-01), Himmelsbach
patent: 2005/0171093 (2005-08-01), Eckhardt et al.
patent: 2005/0187227 (2005-08-01), Himmelsbach et al.
patent: 2005/0203095 (2005-09-01), Eckhardt
patent: 2005/0234108 (2005-10-01), Himmelsbach et al.
patent: 2005/0261352 (2005-11-01), Eckhardt
patent: 2006/0004074 (2006-01-01), Eckhardt
patent: 2006/0058323 (2006-03-01), Eckhardt et al.
patent: 2006/0063787 (2006-03-01), Yoshikawa
patent: 2006/0079541 (2006-04-01), Langkopf
patent: 2006/0094722 (2006-05-01), Yasuda
patent: 2006/0100199 (2006-05-01), Yoshikawa et al.
patent: 2006/0142310 (2006-06-01), Pfrengle et al.
patent: 2006/0173056 (2006-08-01), Kitajima
patent: 2006/0205711 (2006-09-01), Himmelsbach
patent: 2006/0247226 (2006-11-01), Himmelsbach
patent: 2007/0027168 (2007-02-01), Pfrengle et al.
patent: 2007/0088038 (2007-04-01), Eckhardt
patent: 2007/0093659 (2007-04-01), Bonfanti
patent: 2007/0142383 (2007-06-01), Eckhardt
patent: 2007/0185091 (2007-08-01), Himmelsbach et al.
patent: 2007/0219178 (2007-09-01), Muramoto
patent: 2007/0281940 (2007-12-01), Dugi
patent: 2136288 (1995-05-01), None
patent: 2418656 (2002-02-01), None
patent: 2496325 (2004-03-01), None
patent: 2496249 (2004-04-01), None
patent: 2505389 (2004-05-01), None
patent: 2508233 (2004-06-01), None
patent: 2529729 (2004-12-01), None
patent: 2543074 (2005-06-01), None
patent: 2555050 (2005-09-01), None
patent: 2556064 (2005-09-01), None
patent: 2590912 (2006-06-01), None
patent: 10109021 (2002-09-01), None
patent: 10117803 (2002-10-01), None
patent: 0149578 (1985-07-01), None
patent: 0400974 (1990-05-01), None
patent: 0399285 (1990-11-01), None
patent: 0412358 (1991-02-01), None
patent: 0524482 (1993-01-01), None
patent: 0657454 (1995-06-01), None
patent: 1054012 (2000-11-01), None
patent: 1 338 595 (2003-08-01), None
patent: 1514552 (2005-03-01), None
patent: 1537880 (2005-08-01), None
patent: 385302 (1973-04-01), None
patent: 2707641 (1995-01-01), None
patent: S37-4895 (1962-06-01), None
patent: 2003/300977 (2003-10-01), None
patent: 2006/045156 (2006-02-01), None
patent: 91/07945 (1991-06-01), None
patent: 94/03456 (1994-02-01), None
patent: 99/29695 (1999-06-01), None
patent: WO 02/02560 (2002-01-01), None
patent: 02/14271 (2002-02-01), None
patent: 02/24698 (2002-03-01), None
patent: WO 02/068420 (2002-09-01), None
patent: WO 03/004496 (2003-01-01), None
patent: WO 03/024965 (2003-03-01), None
patent: 03/057200 (2003-07-01), None
patent: 03/104229 (2003-12-01), None
patent: 2004/018467 (2004-03-01), None
patent: 2004/018468 (2004-03-01), None
patent: 2004/028524 (2004-04-01), None
patent: 2004/033455 (2004-04-01), None
patent: WO 2004/041820 (2004-05-01), None
patent: 2004/046148 (2004-06-01), None
patent: 2004/048379 (2004-06-01), None
patent: 2004/050658 (2004-06-01), None
patent: 2004/096806 (2004-11-01), None
patent: 2004/108730 (2004-12-01), None
patent: 2004/111051 (2004-12-01), None
patent: 2005/058901 (2005-06-01), None
patent: 2005/082906 (2005-09-01), None
patent: 2005/085246 (2005-09-01), None
patent: 2006/029769 (2006-03-01), None
patent: 2006/048427 (2006-05-01), None
patent: 2006/068163 (2006-06-01), None
patent: 2007/017423 (2007-02-01), None
patent: WO 2008/017670 (2008-02-01), None
Busso et al., American Journal of Pathology 166:433-442 (2005).
U.S. Appl. No. 11/744,700, filed May 4, 2007, Sieger.
U.S. Appl. No. 11/744,701, filed May 4, 2007, Kohlrausch.
Augustyns, K. et al., The Unique Properties of Dipeptidyl-peptidase IV (DPP IV/CD 26) and the Therapeutic Potential of DPP-IV Inhibitors, Current Medicinal Chemistry, vol. 6, No. 4, 1999, pp. 311-327.
Beljean-Leymarie et al., Hydrazines et hydrazones hétérocycliques. IV. Synthèses de dérivés de l'hydrazine dans la série des imidazo[4,5-d]pyridazinones-4, Can. J. Chem., vol. 61, No. 11, 1983, pp. 2563-2566.
Bollag, R.J. et al; “Osteoblast-Derived Cells Express Functional Glucose-Dependent Insulinotropic Peptide Receptors,” Endocrinology, vol. 141, No. 3, 2000, pp. 1228-1235.
Brittain, H.G., “Methods for the Characterization of Polymorphs: X-Ray Powder Diffraction,” Polymorphism in Pharmaceutical Solids, 1999, p. 235-238.
Busso et al., “Circulating CD26 is Negatively Associated with Inflammation in Human and Experimental Arthritis,” Am. J. Path., vol. 166, No. 2, Feb. 2005, pp. 433-442.
Caira, M.R., “Crystalline polymorphism of organic compounds” Topics in Current Chemistry, Springer, Berlin, vol. 198, 1998, p. 163-208.
Conarello, S.L. et al; “Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance,” PNAS 2003; 100:6825-6830; originally published online May 14, 2003; information current as of Dec. 2006. www.pnas.org/cgi/content/full/100/11/6825.
Deacon, C.F. et al; “Dipeptidyl peptidase IV inhabitation as an approach to the treatment and prevention of type 2 diabetes: a historical perspective;” Biochemical and Biophysical Research Communications (BBRC) 294 (2002) 1-4.
DeMeester, I. et al.; “CD26, let it cut or cut it down”, Review: Immunology Today; Aug. 1999, vol. 20, No. 8 pp. 367-375.
Korom, S. et al; Inhibition of CD26/dipeptidyl peptidase IV activity in vivo prolongs cardiac allograft survival in rat recipients1,2, Transplantation, May 27, 1997, vol. 63, No. 10, pp. 1495-1500.
Pospisilik, et al; Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β -Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats; Diabetes, vol. 52, Mar. 2003 pp. 741-750.
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