8-phenylthio-tetrahydroquinolines and anti-allergic use thereof

Details 8-phenylthio-tetrahydroquinolines and anti-allergic use thereof 8-phenylthio-tetrahydroquinolines and anti-allergic use thereof

1987-06-16

1989-07-11

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546178, 546179, C07D21536, A61K 3147

Patent

active

048472689

ABSTRACT:
A compound selected from the group consisting of 8-phenylthio-tetrahydroquinolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, halogen, alkyl of 1 to 6 carbon atoms optionally substituted with hydroxy, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 1 to 6 carbon atoms, alkoxycarbonyl of 2 to 6 carbon atoms, --OH, --NO.sub.2, --NH.sub.2, --COOH, --CN and aminosulfonyl or when R.sub.1 and R.sub.2 are on adjacent carbon atoms form with the said carbon atoms phenyl and their non-toxic, pharmaceutically acceptable acid addition salts having anti-allergic activity.

REFERENCES:
patent: 3509159 (1970-04-01), Kealey

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