8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline d

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

546 79, 546101, A61K 3147

Patent

active

054750032

ABSTRACT:
The disclosed derivatives of 8-phenylcyclopentenoquinolines and 8-phenylcyclohexenoquinolines are useful as anti-inflammatory agents, immunosuppressive agents, anti-allograft, rejection agents, anti-graft-vs-host disease agents, anti-allergic agents, bronchodilation agents, anti-autoimmune agents, and analgetic agents.

REFERENCES:
patent: 4563460 (1986-01-01), Kuhla et al.
patent: 4678791 (1987-07-01), Napier et al.
patent: 5001131 (1991-03-01), Crossley et al.
Nicholson, et al., Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes, TiPS 12:19-27 (1991).
Beavo, et al., Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors, TiPS 11:150-155 (1990).
Livi, et al., Cloning and Expression of cDNA for a Human Low-K.sub.m, Rolipram-Sensitive Cyclic AMP Phosphodiesterase, Mol. Cell. Biol. 10:2678-2686 (1990).
Hirshman, et al., Elevated mononuclear leukocyte phosphodiesterase in allergic dogs with and without airway hyperresponsiveness, J. Allergy Clin. Immunol. 79:46-53 (1987).
Holden et al., Monocyte Localization of Elevated cAMP Phosphodiesterase Activity in Atopic Dermatitis, J. Invest. Dermatol. 87:372-376 (1986).
Glaser, et al., TVX 2706-a new phosphodiesterase inhibitor with anti-inflammatory action Biochemical characterization, 15:341-348 (1984).
Alvarez, et al., Regulation of Cyclic AMP Metabolism in Human Platelets, Mol. Pharmacol. 20:302-309 (1981).
Thompson, et al., Cyclic Adenosine 3':5'-Monophosphate Phosphodiesterase, J. Biol. Chem. 251:4922-4929 (1976).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline d does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline d, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline d will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1359954

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.