8-phenyl-6,9-dihydro-[1,2,4]triazolo[3,4-i]purin-5-one...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S115000, C544S251000, C540S575000, C514S233200, C514S267000

Reexamination Certificate

active

07034016

ABSTRACT:
8-phenyl-6,9-dihydro-[1,2,4]triazolo[3,4-i]purin-5-one derivatives of formula (I):or a pharmaceutically acceptable salt thereof processes for their preparation, pharmaceutical compositions containing them and their use as PDE 5 inhibitors.

REFERENCES:
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patent: 5990118 (1999-11-01), Nagamatsu et al.
patent: 2004/0019034 (2004-01-01), Vidal Juan et al.
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patent: 0 463 756 (1992-01-01), None
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patent: WO 98/49166 (1998-11-01), None
patent: WO 99/62905 (1999-12-01), None
Hamilton, H.W. et al. (1985). “Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application,”J. Med. Chem. 28(8):1071-1079.
Gristwood, R.W. et al. (1992). “Studies on the cardiac actions of flosequinan in vitro,”Br. J. Pharmacol. 105(4):985-991.
Partial Abstract of 463756.

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