8-Oxymethylergolines and process therefor

Details 8-Oxymethylergolines and process therefor 8-Oxymethylergolines and process therefor

1974-12-13

1976-05-25

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424261, C07D45702

Patent

active

039592880

ABSTRACT:
6-methyl-8-alkoxymethylergolines are prepared by reaction of a 6-methyl-8-(substituted)methylergoline with a benzyl quaternary ammonium alkoxide. 6-Methyl-8-phenoxymethylergolines are prepared by reaction of an 8-(substituted)-methylergoline with phenol in the presence of strong base. The new 8-oxymethylergolines of this invention are useful as prolactin inhibitors.

REFERENCES:
patent: 3709891 (1973-01-01), Eich et al.
patent: 3732231 (1973-05-01), Semonsky et al.
patent: 3901894 (1975-08-01), Kornfeld et al.
Zikan et al.; Coll. Czech. Chem. Comm.; Vol. 39, pp. 614-616, (1974).

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