8-Oxa-3-azabicyclo(3.2.1)octane analgesic compositions and metho

Details 8-Oxa-3-azabicyclo(3.2.1)octane analgesic compositions and metho 8-Oxa-3-azabicyclo(3.2.1)octane analgesic compositions and metho

1974-07-12

1976-04-27

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 31535

Patent

active

039535967

ABSTRACT:
Disclosed are compounds, having the following general formula, which are useful as analgesics in living animals. ##SPC1##
Wherein R is a radical selected from the group consisting of aralkyl, aryl, aminoalkyl, arylalkanoyl, heteroaroyl, alkoxy substituted aroyl, alkenyl (C.sub.2 to C.sub.4), halogen substituted aralkyl, guanadinoalkyl, halogen substituted aroyl, alkyl substituted aroyl, halogen substituted arylalkanoyl, hexahydrobenzoyl, arylalkenoyl, o- or p-alkyl substituted phenylalkanoyl, alkyl substituted naphthylalkanoyl, alkanoyl (C.sub.3 to C.sub.20), haloalkyl substituted aroyl, alkoxy substituted aralkyl, heteroaralkyl, anilinocarbonyl, adamantanecarbonyl, arylsulfonyl, carboxyl substituted aroyl, hydroxyl substituted aroyl, alkanoyloxy substituted aroyl, arylglyoxylyl, alicyclic, arylene dicarbonyl-8-oxa-3-azabicyclo(3.2.1)octane, alkylene-8-oxa-3-azabicyclo (3.2.1)octane, alkylene dicarbonyl-8-oxa-3-azabicyclo(3.2.1)octane, and the pharmacologically acceptable acid addition salts thereof.

REFERENCES:
cope et al., I, J. Am. Chem. Soc., Vol. 77, pp. 393-396 (1955).
Cope et al., II, J. Am. Chem. Soc., Vol. 81, pp. 4577-4583 (1959).
Newth et al., J. Chem. Soc. pp. 155-158 (1948).
Khullar et al., J. of Pharm. Sciences, 56, 331 (1967).

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