8-Methoxy-3-phenyl-5-methyl-propargylamino-methyl-2H-1 benzopyra

Details 8-Methoxy-3-phenyl-5-methyl-propargylamino-methyl-2H-1 benzopyra 8-Methoxy-3-phenyl-5-methyl-propargylamino-methyl-2H-1 benzopyra

1979-03-02

1980-08-19

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Virus

26034344, 26034345, A61K 3137, C07D31112

Patent

active

042184673

ABSTRACT:
A novel anticonvulsive medicament, 8-methoxy-3-phenyl-5-methylpropargylaminomethyl-2H-1-benzopyran-2-one, is prepared starting from the (5-chloromethyl) homolog by subjecting the latter compound to refluxing with methylpropargylamine and to subsequent separations, extractions, acidifications and neutralization steps. The toxicity tests are satisfactory and the pharmacological assays encouraging.

REFERENCES:
Chemical Abstract vol. 76, Subject Index Guide, p. 203G.

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