Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-07-15
2008-07-15
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S349000
Reexamination Certificate
active
10526280
ABSTRACT:
8-Hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds are inhibitors of HIV integrase and inhibitors of HIV replication. More particularly, the compounds are of Formula (I): wherein R1, R2, R3, R4, R5and R6are defined herein. The compounds are useful in the prevention and treatment of infection by ITV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.
REFERENCES:
patent: 5294620 (1994-03-01), Ratcliffe et al.
patent: 5821241 (1998-10-01), Claremon et al.
patent: 6841558 (2005-01-01), Anthony et al.
patent: 2003/0055071 (2003-03-01), Anthony et al.
patent: 2004/0034221 (2004-02-01), Anthony et al.
patent: 2005/0010048 (2005-01-01), Zhuang et al.
patent: 2005/0025774 (2005-02-01), Crescenzi et al.
patent: 2006/0024330 (2006-02-01), Wai et al.
patent: WO 00/00478 (2000-01-01), None
patent: WO 02/30426 (2002-04-01), None
patent: WO 02/30930 (2002-04-01), None
patent: WO 02/36734 (2002-05-01), None
patent: WO 02/055079 (2002-07-01), None
patent: WO 03/035076 (2003-05-01), None
patent: WO 03/035077 (2003-05-01), None
Miles, PubMed Abstract (Community Pract, vol. 78, Issue 8, pp. 292-294) Aug. 2005.
van Heeswijk et al., PubMed Abstract (Antivir Ther. 6(4):201-29) Dec. 2001.
Marcus et al., PubMed Abstract (Intervirology 45(4-6):260-6) 2002.
Ratner, L., et al., “Complete Nucleotide Sequence of the AIDS Virus, HTLV-III”, Nature, vol. 313, pp. 277-284, (1985).
Toh, H., et al., “Close Structural Resemblance Between Putative Polymerase of a Drosphila Transposable Genetic Element 17.6 and Pol Gene Product of Moloney Murine Leukemia Virus”, EMBO Journal, vol. 4, No. 5, pp. 1267-1272, (1985).
Power, M.D., et al., “Nucleotide Sequence of SRV-1, a Type D Simian Acquired Immune Deficiency Syndrome Retrovirus”, Science, vol. 231, pp. 1567-1572, (1986).
Pearl, L.H., et al., “A Structural Model for the Retroviral Proteases”, Nature, vol. 329, pp. 351-354, (1987).
Chemical Abstract No. 33-2525, Abstract of Otiai, et al., “Synthesis of 2,5 napthyridine derivatives. II”, J. Pharm. Soc. Japan, vol. 58, pp. 764-770 (1938).
Hammer, S. “Advances in antiretroviral therapy and viral load monitoring”, AIDS, 1996, vol. 10, (suppl 3), pp. S1-S11.
Moyle, G. et al. “Antiretroviral Therapy for HIV Infection”, Drugs, 1998, vol. 55, pp. 383-404.
Mylonakis, E. et al. “Plasma Viral Load Testing in the Management of HIV Infection A Knowledge-Based Approach to Drug Selection and Use”, American Family Physician, 2001, vol. 63, pp. 483-490.
Schooley, R. “Correlation between viral load measurements and outcome in clinical trials of antiviral drugs”, AIDS, 1995, vol. 9, (suppl 2), pp. S15-S19.
Amendment filed Jan. 14, 2008 in U.S. Appl. No. 10/526,275, filed Mar. 1, 2005.
Heber Sheldon O.
Merck & Co. , Inc.
Rao Deepak
Walton Kenneth R.
LandOfFree
8-hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds useful... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 8-hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds useful..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 8-hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds useful... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3912823