8-fluoro and 7,8,10-trifluoro-9-(substituted)-6-oxo-6H-benzo(C)q

Details 8-fluoro and 7,8,10-trifluoro-9-(substituted)-6-oxo-6H-benzo(C)q 8-fluoro and 7,8,10-trifluoro-9-(substituted)-6-oxo-6H-benzo(C)q

1989-02-21

1990-05-08

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544361, A61K 31495, C07D40104

Patent

active

049238680

ABSTRACT:
Novel substituted quinolinecarboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkali metal, alkaline earth metal or lower alkyl; R.sub.2 is hydrogen, benzyl or alkyl(C.sub.1 -C.sub.3); X is hydrogen or fluoro; which have antibacterial activity, intermediates useful in the preparation of the compounds, methods of producing and using the compounds to treat bacterial infections in animals.

REFERENCES:
patent: 4292317 (1981-09-01), Pesson
patent: 4416884 (1983-11-01), Ishikawa et al.
patent: 4426381 (1984-01-01), Matsumura
patent: 4720495 (1988-01-01), Takagi et al.
patent: 4730000 (1988-03-01), Chu
patent: 4774246 (1988-09-01), Chu
Chu et al., CA 109-149473h, "Short Synthesis of 1,2,3,5-Tetrahydro-5-Oxopyrido[1,2-a]quinoline-4-carboxylic Acid . . . ".
Chu et al., J. Heterocyclic Chem., 24, 1537 (1987).

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