8-fluoro and 7, 8, 10-trifluoro-9-(substituted)-6-oxo-6H-benzo-(

Details 8-fluoro and 7, 8, 10-trifluoro-9-(substituted)-6-oxo-6H-benzo-( 8-fluoro and 7, 8, 10-trifluoro-9-(substituted)-6-oxo-6H-benzo-(

1989-12-06

1990-08-14

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544361, C07D45504, C07D40114, A61K 31495

Patent

active

049488945

ABSTRACT:
Novel substituted quinolinecarboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkali metal, alkaline earth metal or lower alkyl; R.sub.2 is hydrogen, benzyl or alkyl (C.sub.1 -C.sub.3); X is hydrogen or fluoro; which have antibacterial activity, intermediates useful in the preparation of the compounds, methods of producing and using the compounds to treat bacterial infections in animals.

REFERENCES:
patent: 4426381 (1984-01-01), Matsumura et al.
patent: 4552879 (1985-11-01), Ishikawa et al.
patent: 4594347 (1986-06-01), Ishikawa et al.
patent: 4691016 (1987-09-01), Stern
patent: 4720495 (1988-01-01), Takagi et al.
Metscher et al., J. Med. Chem., 21, 485 (1978).
Chu et al., J. Heterocyclic Chem., 24, 1537 (1987).

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