8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(p

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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540547, C07D26720, A61K 3155

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active

047043865

ABSTRACT:
This invention relates to 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(substituted phenylsulfinyl)alkanoyl]hydrazides and 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(substituted phenylsulfonyl)alkanoyl]hydrazides that are useful as prostaglandin antagonists and analgesic agents. This invention also relates to 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(substituted phenylthio)alkanoyl]hydrazides that are useful as intermediates in the preparation of the corresponding sulfinyl and sulfonyl compounds.

REFERENCES:
patent: 3534019 (1970-10-01), Coyne et al.
patent: 3917649 (1975-11-01), Mueller
patent: 3989719 (1976-11-01), Mueller
patent: 3992375 (1976-11-01), Mueller
patent: 4045442 (1977-08-01), Mueller
patent: 4125532 (1978-11-01), Mueller
patent: 4170593 (1979-10-01), Mueller
J. H. Sanner, Arch. Int. Pharmacodyn, 180, No. 1, pp. 46-56 (1969).

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