8-Chloroadenosine 3', 5'-cyclic monophosphate preparations

Details 8-Chloroadenosine 3', 5'-cyclic monophosphate preparations 8-Chloroadenosine 3', 5'-cyclic monophosphate preparations

1987-12-21

1989-08-29

Brown, Johannie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 1920, C07H 1900

Patent

active

048618730

ABSTRACT:
The compound 8-Chloroadenosine 3',5'-cyclic phosphate is used to treat malignant tumors in warm blooded animals. Two novel single step syntheses of 8-chloroadenosine 3',5'-cyclic phosphate and other related adenine and adenosine compounds from corresponding adenosine 3', 5'-cyclic phosphate and other respective related adenosine compounds are disclosed.

REFERENCES:
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Kochetkov et al., Organic Chemistry of Nucleic Acids, Part B, pp. 272-274.
Katsaros et al, Fed. Europ. Biochem. Societies, vol. 223(1), pp. 97-103, 1987.
Niles et al., J. Biol. Chem., vol. 254(11), pp. 4324-4326, 1979.
Cancergram of the International Cancer Research Data Bank, Series CB14, #80/03. Mar. 1980.
Abstract #62, T. S. Cho-Chung, et al., Proceedings of ASCO vol. 6, Mar. 1987.
Abstract #180, G. Tortora et al., Proceedings of AACR, vol. 28, Mar. 1987.
Abstract #930, D. Karsaros et al., Proceedings of AACR, vol. 28, Mar. 1987.
Abstract #1323, Y. S. Cho-Chung et al, Proceedings of AACR, vol. 28, 1987.
Muneyama et al, J. Char. Nucleosides Nucleotides, 1(1), 55-60 (1974).
Ruy et al., J. Org. Chem., vol. 46, No. 13 (1981).

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