8-chloro-2,3-benzodiazepine derivatives

Details 8-chloro-2,3-benzodiazepine derivatives 8-chloro-2,3-benzodiazepine derivatives

2011-06-14

2011-06-14

Coleman, Brenda L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S567000

Reexamination Certificate

active

07960375

ABSTRACT:
The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula —NH—R′, wherein R′ stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives. The compounds according to the invention possess AMPA/kainate receptor inhibiting activity.

REFERENCES:
patent: 4322346 (1982-03-01), Korosi et al.
patent: 4614740 (1986-09-01), Lang et al.
patent: 4840948 (1989-06-01), Lang et al.
patent: 6200970 (2001-03-01), Ling et al.
patent: 2566774 (1986-01-01), None
patent: WO 9211262 (1992-07-01), None

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