8-chloro-11-[1-[(5-methy l-3-pyridyl)methyl]-4-piperidyliden]-6,

Details 8-chloro-11-[1-[(5-methy l-3-pyridyl)methyl]-4-piperidyliden]-6, 8-chloro-11-[1-[(5-methy l-3-pyridyl)methyl]-4-piperidyliden]-6,

1993-05-17

1995-04-18

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 93, A61K 31435, C07D40102

Patent

active

054079411

ABSTRACT:
The present invention relates to 8-chloro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidyliden]-6,11-dihydro- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine, to a process for its preparation and to pharmaceutical compositions containing it. This compound is a dual PAF antagonist and antihistamine.

REFERENCES:
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Schumacher et al., J. Org. Chem., 1989, 54, 2242-2244.
Bruneau et al., J. Med. Chem., 1991, 34, 1028-1036.
Rebek et al., J. Am. Chem. Soc., 1985, 107, 7487-7493.
Born, Proceedings of the Physiological Society, Mar. 1962, vol. 23-24, 67 P.
Young et al., Prostaglandins, 1985, 30, 545-551.

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