Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1977-10-20
1979-09-11
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
260153, 544254, C07D48704, A61K 3141, A61K 31505
Patent
active
041675681
ABSTRACT:
8-Azapurin-6-one derivatives of the formula: ##STR1## wherein R.sup.8 represents alkoxy of from 1 to 6 carbon atoms, and R.sup.9 represents cyano, or a group of the formula V, VI, VII, VIII or IX indicated below: ##STR2## wherein R.sup.10, R.sub.13 and R.sup.14 each represents cyano, or alkanoyl or alkoxycarbonyl of from 2 to 6 carbon atoms, R.sup.11 represents hydrogen, cyano, or alkanoyl or alkoxycarbonyl of from 2 to 6 carbon atoms, R.sup.12 represents hydrogen or, when R.sup.11 represents hydrogen, R.sup.12 represents alkyl of from 1 to 6 carbon atoms or alkoxycarbonyl of from 2 to 6 carbon atoms, or the pair of symbols R.sup.11 and R.sup.12 form together an alkylene chain of the formula --(C.sub.q H.sub.2q)-- wherein q is an integer from 3 to 6, R.sup.15 and R.sup.16 each represents hydrogen or alkyl of from 1 to 6 carbon atoms, and Y.sup.1 represents oxygen or sulphur, are new compounds possessing pharmacological properties, in particular properties of value in the treatment of respiratory disorders such as allergic bronchial asthma.
REFERENCES:
patent: 3819631 (1974-06-01), Broughton et al.
patent: 3933822 (1976-01-01), Broughton et al.
patent: 4039544 (1977-08-01), Broughton et al.
patent: 4052390 (1977-10-01), Broughton et al.
Herbst, "Graff, Essays in Biochemistry", 1956, John Wiley & Sons, Inc., N. Y., pp. 141-155.
Ford Roger E.
Knowles Philip
Lunt Edward
Marshall Stuart M.
Daus Donald G.
May & Baker Limited
Turnipseed James H.
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