8-Azabicyclo(3,2,1)oct-2 ene and octane derivatives as...

Details 8-Azabicyclo(3,2,1)oct-2 ene and octane derivatives as... 8-Azabicyclo(3,2,1)oct-2 ene and octane derivatives as...

2005-11-15

2005-11-15

Huang, Evelyn Mei (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S132000, C546S130000, C546S126000, C546S125000, C546S124000

Reexamination Certificate

active

06964972

ABSTRACT:
The invention disclosed herein relates to novel a 8-azabicyclo[3.2.1]oct-2-ene compound of Formula II,whereinR is hydrogen, methyl, ethyl or benzyl; andR1is 3-thienyl, 2-thienyl, 2-(3-methoxymethyl), 3-quinolinyl, 3-benzofuryl, 2-benzofuryl, 3-benzothienyl, 2-benzothienyl, 2-benzothiazolyl, 2-thieno[3.2-b]thienyl, thieno[2.3-b]thienyl, 2-(3-bromo)benzofuryl or 2-(3-bromo)benzothienyl. These compounds are useful for the treatment of conditions or disorders involving the cholinergic system of the central nervous system, pain, inflammatory diseases, diseases caused by smooth muscle contractions and in the cessation of chemical substance abuse.

REFERENCES:
patent: 3133073 (1964-05-01), Archer
patent: 3657257 (1972-04-01), Helsley
patent: 4590270 (1986-05-01), Kompis et al.
patent: 4774249 (1988-09-01), Kompis et al.
patent: 5045546 (1991-09-01), Hrib et al.
patent: 5731317 (1998-03-01), Lu et al.
patent: 6107307 (2000-08-01), Audia et al.
patent: 2002/0035262 (2002-03-01), Yohannes et al.
patent: 2002/0038028 (2002-03-01), Yohannes et al.
patent: 2143 587 (1972-03-01), None
patent: 0122 580 (1984-10-01), None
patent: 0 498 331 (1992-08-01), None
patent: 0 955 301 (1999-11-01), None
patent: 2 247 886 (1992-03-01), None
patent: 2 298 647 (1996-09-01), None
patent: WO 92/21339 (1992-12-01), None
patent: WO 96/31508 (1996-10-01), None
patent: WO 97/11072 (1997-03-01), None
patent: WO 97/13770 (1997-04-01), None
patent: WO 98/46600 (1998-10-01), None
patent: WO 99/65492 (1999-12-01), None
Levin et al. Psychopharmacology 1998, 138(3-4): 217-30.
Repke et al.,J. Org. Chem., vol. 59, pp. 2164-2171 (1994).
Perregaard et al.,J. Med. Chem., vol. 38, pp. 1998-2008 (1995).
Lyle et al.,The Journal of Organic Chemistry, vol. 35, No. 3, pp. 802-805 (Mar. 1970).
Archer et al.,Nucleophilic Agents on 3α-Chlorotropane, vol. 80, pp. 4677-4681 (Sep. 5, 1958).
Zirkle et al.,Synthesis of the Tropane-3-Carboxylic Acids, vol. 27, pp. 1269-1279 (Apr. 1962).
Prokai-Tatrai et al.,Journal of Organometallic Chemistry, vol. 315, pp. 231-236 (1986).
Banach et al.,Journal of Molecular Catalysis, vol. 31, pp. 15-37 (1985).
Hanisch et al.,J.C.S. Perkin II, pp. 1202-1208 (1977).
Freter,J. Org. Chem., vol. 40, No. 17 (1975).
Lyle et al.,Journal of the American Chemical Society, 89:17, pp. 4563-4564 (XP 000612176) (Aug. 1967).
Beckmann-Umlagerung et al.,Helvetica Chimica Acta, vol. 51, No. 1, pp. 153-163 (1968).
The Lancet, Nicotine and Tourette's Syndrome, p. 1046 (Oct. 28, 1989).
Merriam et al.,Psychiatric Annale, vol. 23, No. 4, pp. 171-178 (Apr. 1993).
Adler et al.,Biol. Psychiatry, vol. 32, pp. 607-616 (1992).
Rowell et al.,Journal of Neurochemistry, vol. 43, No. 6, pp. 1593-1595 (1984).
Hall et al.,Biochemical Pharmacology, vol. 21, pp. 1829-1838 (1972).
Bourgoin et al.,Naunyn-Schmiedeberg's Arch. Pharmacol., vol. 296, pp. 91-97 (1977).
Sershen et al.,Neurochemical Research, vol. 17, No. 3, pp. 265-271 (1992).

Affiliated with

Also associated with

Rating

8-Azabicyclo(3,2,1)oct-2 ene and octane derivatives as... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 8-Azabicyclo(3,2,1)oct-2 ene and octane derivatives as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 8-Azabicyclo(3,2,1)oct-2 ene and octane derivatives as... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3480271