8-Aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins

Details 8-Aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins 8-Aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins

1976-03-22

1977-07-05

Garner, Vivian

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602471R, 424312, 260268R, 26029385, 424316, 2603265S, 424319, 2603265SF, 26032643, 536 18, 26032682, 2603457, 2603458, 260401, 2604299, 260439R, 260448R, 260468J, 260472, 260481R, 260484A, 260488F, 26050112, 260514J, 260534M, 260539R, 260556A, 4242485, 424250, 424267, 424274, 424287, 424289, 424295, 424310, 424311, C07C14374, C07C14375, C07C14502

Patent

active

040339963

ABSTRACT:
This invention relates to 8-aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the prevention of thrombus formation, to induce growth hormone release, and as regulators of the immune response.

REFERENCES:
pike, Fortschr. Chem. Org. Naturst., 28, 1970.
Bundy, A. Rep. in Med. Chem. 7, 157 (1972).
Hinman, A. Rev. Biochem., 41,161 (1972).
Horton, Physiol. Rev., 49, 122 (1969).

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