8-aza-11-deoxy prostaglandin analogues

Details 8-aza-11-deoxy prostaglandin analogues 8-aza-11-deoxy prostaglandin analogues

2005-05-31

2005-05-31

Killos, Paul J. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S543000

Reexamination Certificate

active

06900336

ABSTRACT:
This invention relates to compounds which are generally EP4receptor agonists and which are represented by Formula I:wherein A is a —CH2—CH2—, or —CH═CH—; B is absent, an aryl, or heteroaryl group; R1is alkyl, alkenyl, alkynyl, cycloalkylalkyl, heterocyclylalkyl, aryl, arylalkyl or heteroaryl, when B is aryl or heteroaryl and R3, R4, R5and R6are not simultaneously hydrogen, or R1is heterocyclylalkyl, aryl, or heteroaryl when B is absent and R3, R4, R5and R6are simultaneously hydrogen; and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

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