8-arylxanthines

Details 8-arylxanthines 8-arylxanthines

1987-10-01

1988-11-08

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544272, 544273, 514263, 514265, C07D23936, A61K 3152

Patent

active

047835303

ABSTRACT:
1,3-alkylsubstituted-8-(3,4-,3- or 4-substituted phenyl)xanthines and pharmaceutically acceptable salts of such compounds are disclosed. The 3-substituents are hydrogen, dimethylaminomethyl, or 2,3-dihydroxypropyloxy. The 4-substituents are selected from hydroxy, cyano, --NHCON(R.sub.5).sub.2, --C(.dbd.NH)N(R.sub.5).sub.2, --NH--C(.dbd.NH)N(R.sub.5).sub.2, with each R.sub.5 independently being hydrogen or an alkyl group of one to three carbons and provided that when the 3-substituent is hydrogen the 4-substituent is not hydroxy or hydrogen.
The compounds are potent adenosine receptor antagonists having relatively low lipophilicity. The compounds are intended for use as bronchodilators and cardiotonics.

REFERENCES:
patent: 4593095 (1986-06-01), Snyder et al.
Copy provided in parent case.

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