8-amino decahydroquinolines having central nervous system analge

Details 8-amino decahydroquinolines having central nervous system analge 8-amino decahydroquinolines having central nervous system analge

1988-07-11

1990-11-06

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514314, 546164, A61K 3147, C07D21700

Patent

active

049687000

ABSTRACT:
Novel enantiomeric and diastereoisomeric forms of decahydroquinolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are connected form a 5 to 6 member heterocycle optionally including another heteroatom and optionally substituted, A is selected from the group consisting of --(CH.sub.2).sub.n -- and alkylene substituted with an alkyl and having 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, naphthyl indenyl, monocyclic heterocycle of 5 to 6 members and a bicyclic heterocycle all being unsubstituted or substituted by one or more substituents and their non-toxic, pharmaceuically acceptable acid addition salts and quaternary ammonium salts having central analgesic properties.

REFERENCES:
patent: 3991065 (1976-11-01), Curran et al.
patent: 4145435 (1979-03-01), Szmuszkovicz
patent: 4173636 (1979-11-01), Prost
patent: 4359476 (1982-11-01), Kaplan et al.
patent: 4845099 (1989-07-01), Ruger et al.

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