8-alkoxyquinolonecarboxylic acid and salts thereof

Details 8-alkoxyquinolonecarboxylic acid and salts thereof 8-alkoxyquinolonecarboxylic acid and salts thereof

1990-10-22

1991-08-27

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544225, 544226, 544363, 546 8, 556423, 560 53, 562840, 562473, 564176, 558423, C07D40304

Patent

active

050434500

ABSTRACT:
Quinolonecarboxylic acid derivatives of the following formula, ##STR1## wherein R indicates a hydrogen atom or lower alkyl group, R.sup.1 indicates a lower alkyl group, R.sup.2 indicates a hydrogen atom, amino group or nitro group, X indicates a halogen atom, and Z indicates a halogen atom, piperazino group, N-methylpiperazino group, 3-methylpiperazino group, 3-hydroxypyrrolidino group, or pyrrolidino group of the following formula, ##STR2## (here, n is 0 or 1, R.sup.3 indicates a hydrogen atom or lower alkyl group, R.sup.4 indicates a hydrogen atom, lower alkyl group or substituted lower alkyl group and R.sup.5 indicates a hydrogen atom, lower alkyl group, acyl group or alkoxycarbonyl group), the hydrates and pharmaceutically acceptable salts thereof are useful as antibacterial agents.

REFERENCES:
patent: 4665079 (1987-05-01), Culbertson et al.
patent: 4777175 (1988-10-01), Culbertson et al.
patent: 4822801 (1989-04-01), Domagala et al.
patent: 4851418 (1989-07-01), Sanchez
patent: 4997943 (1981-03-01), Iwata et al.

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