8[2-(imidazolyl)thio] and 8[2-(thiazolyl)thio]-5,6,7,8-tetrahydr

Details 8[2-(imidazolyl)thio] and 8[2-(thiazolyl)thio]-5,6,7,8-tetrahydr 8[2-(imidazolyl)thio] and 8[2-(thiazolyl)thio]-5,6,7,8-tetrahydr

1986-02-26

1988-06-14

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546176, 546177, 546178, C07D40314, C07D41712, A61K 31415, A61K 31425

Patent

active

047512334

ABSTRACT:
Novel 8-thiotetrahydroquinolines of the formula ##STR1## wherein X is selected from the group consisting of ##STR2## Alk is alkyl of 1 to 6 carbon atoms, R.sub.1 and R.sub.2 are Alk individually selected from the group consisting of hydrogen and aryl or taken together with the carbon atoms to which they are attached form a phenyl optionally substituted with at least one member of the group consisting of alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, halogen, ##STR3## and Alk' is alkyl of 1 to 6 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having antiallergic activity and their preparation.

REFERENCES:
patent: 3857877 (1974-12-01), Somasekhara
patent: 3991060 (1976-11-01), Curran et al.

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