8,12-Diisoprostanoic acid derivatives

Details 8,12-Diisoprostanoic acid derivatives 8,12-Diisoprostanoic acid derivatives

1972-12-15

1978-05-16

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603433P, 26034622, 260456R, 260456P, 26050117, 26050118, 260520B, 424305, 424317, 542426, 560121, 560231, C07C17700, A61K 3119, A61K 31215

Patent

active

040898962

ABSTRACT:
Optically active 8,12-diisoprostanoic acids and derivatives, processes for making same, pharmaceutical compositions containing same, and intermediates for producing same are disclosed. The acids include, for instance, 5c,13t-11.alpha.,15S-dihydroxy-9-oxo-8,12-diisoprostadienoic acid. The compounds of the present invention can be used in the same uses as the natural prostaglandins, including the treatment of asthma, parturition to facilitate child bearing labor and as abortion agents.

REFERENCES:
Corey et al. I, J. Org. Chem. 37, 3043, (1972).
Corey et al. II, JACS 92, 387 (1970).

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