8,10-Dideazaminopterins

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

544279, C07D47104, C07D48704, A61K 31505

Patent

active

045322414

ABSTRACT:
10-Alkyl-8,10-dideazaminopterins of the formula ##STR1## where R is hydrogen or alkyl of 1 to about 8 carbon and their carboxylate and acid addition salts are described. These compounds exhibit antineoplastic activity that is similar to, but more effective than, methotrexate.

REFERENCES:
patent: 4460591 (1984-07-01), DeGraw et al.

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