Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1982-08-26
1984-07-17
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544260, 544279, C07D47104, C07D48704, A61K 31505
Patent
active
044605919
ABSTRACT:
8,10-Dideazaminopterins of the formula ##STR1## where R is hydrogen or alkyl of 1 to about 8 carbon atoms and their carboxylate and acid addition salts are described. These compounds exhibit antineoplastic activity that is similar to but more effective than methotrexate.
REFERENCES:
J. I. DeGraw and F. M. Sirotnak, Cancer Treatment Reports, 62, 1047, (1978).
J. I. DeGraw, R. L. Kisliuk, Y. Gaumont and C. M. Baugh, J. Med. Chem., 17, 470, (1974).
J. I. DeGraw, R. L. Kisliuk, V. H. Brown and Y. Gaumont, Chem. Biol. Pteridines, 6, 229, (1979).
A. Srinivasan and A. D. Broom, J. Org. Chem., 46, 1777, (1981).
DeGraw Joseph I.
Kelly Lawrence F.
Sirotnak Francis M.
Daus Donald G.
Gibson S. A.
SRI - International
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