7H-pyrrolo[2,3-d]pyrimidine derivatives

Details 7H-pyrrolo[2,3-d]pyrimidine derivatives 7H-pyrrolo[2,3-d]pyrimidine derivatives

2004-02-20

2008-01-29

Coleman, Brenda L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S265100, C544S280000

Reexamination Certificate

active

07323469

ABSTRACT:
The invention relates to 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula Iwherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumor.

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Caravatti et al., “Pyrrolo[2,3-d]pyrimidine and Pyrazolo[3,4-d]pyrimidine Derivatives as Selective Inhibitors of the EGF Receptor Tyrosine Kinase,” ACS Symposium series, 796, pp. 231-244 (2001).

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