7H-1,3,4-Thiadiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic compou

Details 7H-1,3,4-Thiadiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic compou 7H-1,3,4-Thiadiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic compou

1978-12-12

1981-07-28

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 586, 544255, 2602433, C07D51304

Patent

active

042811201

ABSTRACT:
Derivatives of 7H-1,3,4-thiadiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid having basic substituents in the 2-position, the alkyl esters and/or pharmaceutically useable salts of these compounds are new substances having immunstimulating properties, being especially valuable for antiinfectious therapy in mammals including man. The new products are prepared by reacting 2-amino-5-(basically substituted)-1,3,4-thiadiazoles with dialkylacetylenedicarboxylates and splitting the ester grouping in the obtained compound if desired and/or forming pharmaceutically acceptable salts.

REFERENCES:
Chemical Substance Index, 1972-1976, 9th Collective, p. 8031cs.
Okahe et al., Chem. Abstracts, vol. 79, (1973), No. 32002z.

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