Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-12-21
2008-08-12
Qazi, Sabiha (Department: 1612)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C540S041000, C540S043000, C549S265000, C562S553000, C562S554000
Reexamination Certificate
active
07411062
ABSTRACT:
The present invention involves intermediates, including a 7α-substituted steroid (II),and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
REFERENCES:
patent: 3053856 (1962-09-01), Payne et al.
patent: 3300489 (1967-01-01), Holden
patent: 3413288 (1968-11-01), Creger
patent: 3759791 (1973-09-01), Marscheck
patent: 3897417 (1975-07-01), Warnant et al.
patent: 3972878 (1976-08-01), Schimann et al.
patent: 4270994 (1981-06-01), Behling
patent: 4502989 (1985-03-01), Kamata et al.
patent: 4559332 (1985-12-01), Grob et al.
patent: 4874754 (1989-10-01), Nique et al.
patent: 5565588 (1996-10-01), Batist et al.
patent: 5616742 (1997-04-01), Fu et al.
patent: 5981744 (1999-11-01), Ng et al.
patent: 6010844 (2000-01-01), Fischer et al.
patent: 6180780 (2001-01-01), Ng et al.
patent: 6716829 (2004-04-01), Rocha et al.
patent: 7112670 (2006-09-01), Pearlman et al.
patent: 7129345 (2006-10-01), Ng et al.
patent: 7196208 (2007-03-01), Wuts
patent: 7235655 (2007-06-01), Pearlman et al.
patent: 2404947 (1974-08-01), None
patent: 2443746 (1975-03-01), None
patent: 2349022 (1975-04-01), None
patent: 2932925 (1980-02-01), None
patent: 3344057 (1984-06-01), None
patent: 0122232 (1984-10-01), None
patent: 0123734 (1984-11-01), None
patent: 0165902 (1985-12-01), None
patent: 280618 (1988-02-01), None
patent: 9825948 (1998-06-01), None
Edward A. Brown, et al., “Sterodial Aldosterone Blockers VII”, J. Med. Chem. 1963, vol. 6, pp. 732-735.
Edward A. Brown, et al., “Sterodial Aldosterone Blockers III”, J. Org. Chem, 1960, vol. 25 (1), pp. 96-99.
D.H. Peterson, et al., “Microbiological Transformations of Steroids. VI. Preparation of 11{acute over (α)}-Hydroxy-6-dehydroprogesterone”, J of the Am Chemical Society, vol. 75 (2), pp. 419-421, 1953.
R.M. Weir et al., “7{acute over (α)}-Carboalkoxy Steroidal Spirolactones As Aldosterone Antagonists”, J of Med. Chemistry, vol. 18(8), pp. 817-821, 1975.
D. Van Leusen et al., “Chemistry of Sulfonylmethyl Isocyanides. 33. Synthesis of 17-(isocyanotosylmethylene) Steroids: Precursors to Pregnane Derivatives” Recueil Des Travaux Chimiques Des Pays-Bas, vol. 110(10), pp. 393-401, Oct. 1991.
K. Nickish et al., “Aldosterone Antagonists.3.Synthesis and Activities of Steroidal 7{acute over (α)}-(Alkoxycarbonyl)-15,16-Methylene Spirolactones”, J. of Med. Chemistry, vol. 33(2), pp. 509-513, Feb. 1990.
Arias, L. et al., “Epoxidation of Alkenes with Trichloracetonitrile/Hydrogen Peroxide In a Neutral Biphasic Solvent System”, J. Org. Chem., vol. 48, pp. 888-890, 1983.
Carruthers, N. et al., “Synthesis of Corticoids from 9{acute over (α)}-Hydroxyandrost-4-ene-8, 17-dione”, J. Org. Chem., vol. 57, pp. 961-965, 1992.
DeGasparo, M. et al, “Antialdosterones: Incidence and Prevention of Sexual Side Effects”, J. Steroid Biochem, vol. 32(13), pp. 223-227, 1989.
Nagata, W. et al., “Angular-Substituted Polycyclic Compounds. I. Cyanation of Δ-Cholesten-3-One”, J. of Organic Chemistry, vol. 26, pp. 2413-2420, 1961.
Ogata, Y. et al., “The Alkali Phosphate-Catalyzed Epoxidation and Oxidation By a Mixture of Nitrile and Hydrogen Peroxide”, Tetrahedron, vol. 20, pp. 2065-2068, 1964.
Payne et al., “Reactions of Hydrogen Peroxide. VII. Alkali-Catalyzed Epoxidation and Oxidation Using a Nitrile as a Co-reactant”, J. Org. Chem. vol. 26, pp. 659-663, 1961.
deGasparo et al, “Three New Epoxy-Spirolactone Derivatives: Characterization in Vivo and in Vitro”, J. of Pharmacology and Experimental Therapeutics, vol. 240(2), pp. 650-656, 1987.
Dingas et al, “Preparation de carboxyethnyl-7 steroids”, Chimie Organique Biologique, vol. 11, pp. 735-737.
Gritsan et al., “Experimental and Quantum Chemical Study of the Reactions of 1,10-Anthraquinones with Alcohols and Amines”, Tetrahedron, vol. 51(10), pp. 3061-3076, 1995.
Solo, et al., “7{acute over (α)}Alkyltestosterone Derivatives: Synthesis and Activity as Androgens and As Aromatase Inhibitors”, Steroids, vol. 40(6), pp. 603-613, 1982.
J. Org. Chem, vol. 226, 1961, pp. 2549-2550.
J. Org. Chem, vol. 29, 1964, pp. 601-604.
Heterocycles, vol. 25, 1987, pp. 399-407.
Bull. Soc. Chim. Fr., vol. 131, 1994, pp. 900-909.
Journal of the American Chemical Society, vool. 94:13, 1972, pp. 4654-4672.
Tetrahedron, vol. 49, 1993, pp. 9955-9972.
Tetrahedron Letters, vol. 29, 1988, pp. 1533-1536.
Helvetica Chimica Acta, vol. 80, 1997, pp. 566-585.
Journal of the American Chemical Society, vol. 79, 1957, pp. 3121-3124.
Journal of the American Chemical Society, vol. 82, 1960, pp. 6136-6142.
J. Org. Chem., vol. 27, 1962, pp. 1192-1197.
J. Org. Chem., vol. 61, 1996, pp. 9126-9134.
Heterocycles, vol. 34, 1992, pp. 895-898.
Journal of the American Chemical Society, vol. 101, 1979, pp. 259-260.
Journal of the American Chemical Society, vol. 107, 1985, pp. 7762-7764.
Tetrahedron Letters, vol. 34, 1993, pp. 7323-7326.
Carbohydrate Research, vol. 150, 1986, pp. 162-171.
Tetrahedron Letters, vol. 22, 1981, pp. 141-144.
Journal of the Amercan Chemcal Society, vol. 109, 1987, pp. 2082-2089.
Tetrahedron Letters, vol. 39, 1998, pp. 7013-7016.
J. Org. Chem., vol. 54, 1989, pp. 2085-2091.
J. Org. Chem., vol. 63, 1998, pp. 7505-7515.
Chemistry Letters, 1983, pp. 1771-1774.
Drugs of the Future, vol. 24, 1999, pp. 488-501.
Bulletin of the Chemical Society of Japan, vol. 52, 1979, pp. 3377-3380.
J. Org. Chem., vol. 29, 1964, pp. 2187-2195.
Tetrahedron Letters, vol. 23, 1962, pp. 1065-1069.
J. Flourine Chemistry, vol. 109, 2001, pp. 25-31.
U.S. Appl. No. 11/614,446: 7α-Furyl or Thienyl-substituted steriod compounds.
U.S. Appl. No. 11/614,490: 7α-Enedione-Substituted Steroid Compounds.
U.S. Appl. NO. 11/614,510: 7α-Hydroxyacetyl and 7α-Hydroperoxyacetyl-Substituted Steroid Compounds.
U.S. Appl. No. 11/614,538: Process to Prepare Eplerenone.
Havens Jeffrey L.
Mackey Sonja S.
Padilla Amphlett Greg
Pearlman Bruce Allen
Wu Haifeng
Benson Gregg C.
Nardone Rona A.
Pfizer Inc.
Qazi Sabiha
LandOfFree
7α-biscarbonyl-substituted steroid compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 7α-biscarbonyl-substituted steroid compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 7α-biscarbonyl-substituted steroid compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4018823