7-vinylidene cephalosporins and methods of using the same

Details 7-vinylidene cephalosporins and methods of using the same 7-vinylidene cephalosporins and methods of using the same

1994-12-09

1997-01-28

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514201, 514208, 514209, 540215, 540221, 540229, 540230, C07D50100, A61K 31545

Patent

active

055978177

ABSTRACT:
Cephalosporins with an exocyclic allene in the 7-position and their pharmaceutically active salts are potent inhibitors of .beta.-lactamases and are therefore useful in the treatment of penicillin resistant infections.

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patent: 5446037 (1995-08-01), Maiti et al.
Srinivasan Chandrasekaran, et al; "Synthesis of Substituted .beta.-Lactams by Addition of Nitromethane to 6-Oxopenicillanates and 7-Oxocephalosporanates"; J. Org. Chem., vol. 42, No. 24; pp. 3972-3974; 1977.
Shoichiro Uyeo, et al; "Synthesis of (6R, 7R)-Phenylacetylmethyl-3(1-Methyl-1H-Tetrazol-5-Yl)Thiomethyl-1-Oxa-1-Deth iacephalosporanic Acid"; Heterocycles, vol. 13; pp. 255-257; 1979.
H. E. Applegate, et al; "7-[2-Hydroxyethyl]Cephalosporanic Acid Derivatives"; Tetrahedron Letters; No. 19; pp. 1637-1640; 1979.

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