7'-Trifluoromethyl-spiro[imidazolidine-4,3'-indoline]-2,2',5-tri

Details 7'-Trifluoromethyl-spiro[imidazolidine-4,3'-indoline]-2,2',5-tri 7'-Trifluoromethyl-spiro[imidazolidine-4,3'-indoline]-2,2',5-tri

1983-05-06

1985-09-03

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548101, 548309, 548485, 548486, A61K 31415, C07D48710

Patent

active

045393290

ABSTRACT:
The invention concerns novel trifluoromethyl derivatives of 1'-halogenobenzyl-spiro[imidazolidine-4,3'-indoline]-2,2',5-trione (I), their pharmaceutically acceptable salts, and non-toxic, biodegradable precursors thereof. The derivatives are potent inhibitors of the enzyme aldose reductase and are useful in treating or preventing certain complications of diabetes. The invention also provides pharmaceutical compositions and processes for the manufacture of the derivatives.

REFERENCES:
patent: 3767653 (1973-10-01), Krapcho
patent: 4053613 (1977-10-01), Rovnyak et al.
patent: 4386100 (1983-05-01), Brittain et al.
Yale, H., J. Med. Chem., 1, 121-133 (1959).

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