7-Substituted-ureido-3-carbamoyloxymethyl cephalosporin antibiot

Details 7-Substituted-ureido-3-carbamoyloxymethyl cephalosporin antibiot 7-Substituted-ureido-3-carbamoyloxymethyl cephalosporin antibiot

1976-02-20

1977-12-06

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424246, 544 22, A61K 31545, C07D50120, C07D50132, C07D50134

Patent

active

040616304

ABSTRACT:
Cephalosporin compounds represented by the formula ##STR1## wherein R is an acylamino group ##STR2## and R' is for example phenyl or furyl, R" is H or CH.sub.3 ; or R is a substituted ureido group ##STR3## and R" is H or CH.sub.3, R"' is e.g., C.sub.1 -C.sub.3 alkyl; or R is a cyclic ureido group, e.g., imidazolidine-2-one-1-yl and wherein R.sub.1 is phenyl, substituted phenyl, thienyl, or furyl; are broad spectrum antibiotics exhibiting an expanded spectrum of activity vs. gram-negative microorganisms.

REFERENCES:
patent: 3673183 (1972-06-01), Erickson
patent: 3687949 (1972-08-01), Holdrege
patent: 3706746 (1972-12-01), Bosshardt et al.
patent: 3741962 (1973-06-01), Breuer
patent: 3956292 (1976-05-01), Cooper
patent: 3966709 (1976-06-01), Konig et al.

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