7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimid

Details 7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimid 7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimid

1989-10-31

1991-01-15

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544280, C07D48702, A61K 31495

Patent

active

049854348

ABSTRACT:
Disclosed is a compound containing 2-amino-7-(R)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-one wherein R is optionally substituted cyclohexenyl or cyclohexyl, a pharmaceutical composition containing the compound, and a method for the selective suppresion of mammalian T-cell function without diminished effect on humoral immunity which involves administering the composition to a mammal.

REFERENCES:
patent: 4921858 (1990-05-01), Malone et al.
patent: 4923872 (1990-05-01), Kostlan et al.
Lim et al., J. Org. Chem., vol. 44, No. 22, 1979, p. 3826.
Lim et al., Tetrahedron Letters, vol. 21, pp. 1013-1016 (1980).
Lim et al., J. Org. Chem., 1983, 48, 780-788.

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