7-substituted camptothecin and camptothecin analogs and...

Details 7-substituted camptothecin and camptothecin analogs and... 7-substituted camptothecin and camptothecin analogs and...

2006-06-27

2006-06-27

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S279000

Reexamination Certificate

active

07067666

ABSTRACT:
Methods of forming camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.

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Walter Loos et al Structural Identification and Biological Activity of . . . Clinical Cancer Research vol. 8 pp. 856-862 Mar. 2002.

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