7-Substituted aminoacetamido oxadethiacephalosporins

Details 7-Substituted aminoacetamido oxadethiacephalosporins 7-Substituted aminoacetamido oxadethiacephalosporins

1977-08-22

1980-10-07

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424851, 544 90, 542419, A61K 31535, C07D26504, C07D41302

Patent

active

042268648

ABSTRACT:
Antibacterial 7-substituted aminoacetamido oxadethiacephalosporins of the formula: ##STR1## [wherein R is substituted amino, substituted phenyl, or 5- or 6-membered hetero ring; Ar is aryl; Y is hydrogen or methoxy; Het is 5- or 6-membered aromatic hetero ring; and Z is hydroxy or carboxy protecting group] preparable e.g. by acylation of 7.alpha.-methoxy-7.beta.-amino-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives, are highly active against gram-positive and gram-negative bacteria, especially those resistant to other cephalosporins and penicillins.

REFERENCES:
patent: 3996218 (1976-12-01), Breuer et al.
patent: 4013653 (1977-03-01), Wolfe
patent: 4015000 (1977-03-01), Kocsis et al.
patent: 4032521 (1977-06-01), Christenen et al.
patent: 4087424 (1978-05-01), Saikawa et al.
patent: 4103008 (1978-07-01), Toshiyasu et al.
patent: 4110327 (1978-08-01), Saikawa et al.
Firestone et al., J. Med. Chem., vol. 20, pp. 551 to 556 (4-77).
Lednicer et al., The Organic Chemistry of Drug Synthesis, pp. 408 to 415, 417 to 422 (p. 416 missing), John Wiley and Sons, NY (1977).
Cama et al., J. Am. Chem. Soc., vol. 96, pp. 7582-7584 (1974).
Kim et al., Tetrahedron Letters No. 5, pp. 409-412 (1978).
Chemical Abstracts, vol. 81, Abst. No. 37560f (1974) (Abst. of Ger. Offen. 2,355,209, apparent German equivalent of Japanese Patent 133,593 above).

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