7-(Substituted)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamines

Details 7-(Substituted)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamines 7-(Substituted)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamines

1977-06-27

1978-10-03

Coughlan, Jr., Paul M.

Harness for working animal

424251, 544250, C07D23995, C07D48704

Patent

active

041185617

ABSTRACT:
Pyrrolo[3,2-f]quinazoline-1,3-diamine and the 7-(substituted) and 7,8-disubstituted derivatives thereof, possess anti-bacterial activity in vitro. The invention also provides compounds having other biological effects, such as synergism in vivo with sulfa drugs against bacterial infections, activity in vivo against malarial infections, and anti-cancer activity in vivo. In addition, the compounds show anti-folic acid activity in in vitro tests.

REFERENCES:
patent: 2945859 (1960-07-01), Hitchings et al.
patent: 3505330 (1970-04-01), Dauoll

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