7-phenyl-7-(3-pyridyl)-6-heptenoic acid or derivatives thereof w

Details 7-phenyl-7-(3-pyridyl)-6-heptenoic acid or derivatives thereof w 7-phenyl-7-(3-pyridyl)-6-heptenoic acid or derivatives thereof w

1983-06-09

1988-02-23

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546267, 546269, 546283, 546342, 546284, C07D21355, A01N 3144

Patent

active

047270780

ABSTRACT:
Novel compound of the formula: ##STR1## wherein R.sup.1 is pyridyl group, R.sup.2 is a phenyl group, a thienyl group, a furyl group, a naphthyl group, a benzothienyl group or pyridyl group, which may optionally have a lower alkoxy group, a lower alkyl group, a halogen atom, trifluoromethyl group, a lower alkenyl group or methylenedioxy group, R.sup.3 is hydrogen atom or a lower alkyl group, and n is an integer of 0 to 6, Y is sulphur atom, methylene group or a group of the formula: ##STR2## wherein R.sup.4 is hydrogen atom or acetyl group, and m is 0 or 1, and their pharmaceutically acceptable salts have an inhibitory action on bio-synthesis of thromboxane A.sub.2 (TXA.sub.2) and an effect of accelerating the productivility of prostaglandin I.sub.2 (PGI.sub.2), and can be used for mammals to the prophylaxis or therapy of thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardiac infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).

REFERENCES:
patent: 4518602 (1985-05-01), Terao et al.
Terao et al., Chem. Abstracts, vol. 100, (19), Abst. 156,509s, May 7, 1984.
Terao et al., Chem. Abstracts, vol. 100, (210, Abst. 174,676y, May 21, 1984.
Terao et al., Chem. Abstracts, vol. 102, (11), Abst. 91,907q, Mar. 18, 1985.
J. Med. Chem. 24 1139 1981--Iizuka et al.--Highly Selective Inhibitors of Thromboxane Synthetase, 1. Imidazol Derivatives.
J. Med. Chem. 24 1149 1981--Iizuka et al.--Highly Selective Inhibitors of Thromboxane Synthetase, 2. Pyridine Derivatives.

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