7-oxo-4-thia-azabicyclo[3,2,0]hept-2-ene derivatives

Details 7-oxo-4-thia-azabicyclo[3,2,0]hept-2-ene derivatives 7-oxo-4-thia-azabicyclo[3,2,0]hept-2-ene derivatives

1987-12-01

1989-07-18

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540310, 514195, C07D49900, A61K 31425

Patent

active

048494194

ABSTRACT:
A compound of formula I ##STR1## with R.sup.1 being an alkyl group substituted by one or more substituents and esters thereof at the 2-carboxy group or at the 8-hydroxy group or both; and salts thereof. Compounds I have antibacterial effect. Various intermediates are described. This compound of the formula I, or an ester at the 2-carboxy group or at the 8-hydroxy group or both or a salt thereof is produced by reacting a compound of formula II or of formula IX ##STR2## in which R represents a hydrogen atom or a carboxy protecting group, R.sup.3 represents an activated carboxylic acid group, R.sup.4 represents an alkyl group having 1 to 4 carbon atoms, or a phenyl group which may be unsubstituted or substituted, R.sup.15 represents a phenyl group or an alkyl group having from 1 to 4 carbon atoms, and X represents an oxygen or sulphur with an amine of the formula III R.sup.1 NH.sub.2 (III) to give a compound of formula I, or an ester thereof of formula Ia ##STR3##

REFERENCES:
patent: 4585767 (1986-04-01), Cooke et al.

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