7-oxabicycloheptyl substituted heterocyclic thioamide prostaglan

Details 7-oxabicycloheptyl substituted heterocyclic thioamide prostaglan 7-oxabicycloheptyl substituted heterocyclic thioamide prostaglan

1990-09-19

1994-03-01

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514374, 514397, 548200, 548236, 5483114, C07D40304, C07D41304, C07D41704, A61K 31425

Patent

active

052907996

ABSTRACT:
7-Oxabicycloheptane substituted prostaglandin analogs useful in treating thrombotic and vasospastic disease have the structural formula ##STR1## wherein m is 1, 2 or 3; n is 1, 2, 3 or 4; Z is --(CH.sub.2).sub.2 --, --CH.dbd.CH-- or ##STR2## wherein Y is O, a single bond or vinyl, with the proviso that when n is O, if Z is ##STR3## then Y cannot be O, and when Z is --CH.dbd.CH--, n is 1, 2, 3 or 4; and when Y=vinyl, n=0; R is CO.sub.2 H, CO.sub.2 lower alkyl, CH.sub.2 OH, CO.sub.2 alkali metal, CONHSOR.sup.3, CONHR.sup.3a or --CH.sub.2 -5-tetrazolyl, X is O, S or NH; and where R.sup.1, R.sup.2, R.sup.3 and R.sup.3a are as defined herein.

REFERENCES:
patent: 4654355 (1987-03-01), Nakane
patent: 4663336 (1987-05-01), Nakane
patent: 4738978 (1988-04-01), Nakane
patent: 4837234 (1989-06-01), Jones
patent: 5100889 (1992-03-01), Misra
AS Belo Bioorg Chem, 4, Mar. 1981-SU278256 (23, Nov. 1987) CO7c-177 CO7d-261/06.
Chem. Abs. SA Selects: Prostaglandins Issue 12, 1988, 108:198903m. Kuz'mitskii, B. B. et al.
CA Selects: Prostaglandins, Issue 12, 1988, 108:204363d, Lakhvich, F. A. et al.

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