7-oxabicycloheptyl substituted heterocyclic amide prostaglandin

Details 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin

1991-06-12

1992-10-27

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 79, 514 89, 514 92, 514 94, 514183, 514212, 514399, 540480, 540602, 540603, 546196, 548112, 548236, 5483114, 549463, C07D41304

Patent

active

051589672

ABSTRACT:
7-Oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs are provided which are thromboxane A.sub.2 (TXA.sub.2) receptor antagonists or combined thromboxane A.sub.2 receptor antagonist/thromboxane synthetase inhibitors and have the structural formula ##STR1## wherein R is SO.sub.3 H, P(O)OR.sup.3 OH or P(O)R.sup.4 OH, X is O or NH, and Z, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein.

REFERENCES:
patent: 4416896 (1983-11-01), Nakane et al.
patent: 4418076 (1983-11-01), Nakane et al.
patent: 4463015 (1984-07-01), Haslanger et al.
patent: 4474804 (1984-10-01), Das et al.
patent: 4522949 (1985-06-01), Das et al.
patent: 4536513 (1985-08-01), Das et al.
patent: 4556675 (1985-12-01), Snitman et al.
patent: 4663336 (1987-05-01), Nakane
patent: 4663337 (1987-05-01), Das et al.
patent: 5100889 (1992-03-01), Misra et al.
Derwent Abstr. As Belo Bioorg Chem, Apr. 3, 1981-SU278256 (Nov. 23, 1987).
Chem Abs. SA Selects: Prostaglandins Issue 12, 1988, 108:198903m. Kuz'mitskii, B. B. et al.
CA Selects: Prostaglandins, Issue 12, 1988, 108:204363d, Lakhvich, F. A. et al.

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