7-oxabicycloheptyl substituted heterocyclic amide or ester prost

Details 7-oxabicycloheptyl substituted heterocyclic amide or ester prost 7-oxabicycloheptyl substituted heterocyclic amide or ester prost

1990-06-18

1992-03-31

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514374, 548200, 548236, C07D41304, C07D41704, A61K 3142, A61K 31425

Patent

active

051008890

ABSTRACT:
7-Oxabicycloheptane substituted prostaglandin analogs useful in treating thrombotic and vasopastic disease have the structural formula ##STR1## wherein m is 1, 2 or 3; n is 1, 2, 3 or 4; Z is --(CH.sub.2).sub.2 --, --CH.dbd.CH-- or ##STR2## wherein Y is O, a single bond or vinyl, with the proviso that when n is 0, if Z is ##STR3## then Y cannot be O, and Z is --CH.dbd.CH--, n is 1, 2, 3 or 4; and when Y=vinyl, n=0; R is CO.sub.2 H, CO.sub.2 lower alkyl, CH.sub.2 OH, CO.sub.2 alkali metal, CONHSOR.sup.3, CONHR.sup.3a or --CH.sub.2 --5-tetrazolyl, X is O, S or NH; and where R.sup.1, R.sup.2, R.sup.3 and R.sup.3a are as defined herein.

REFERENCES:
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patent: 4463015 (1984-07-01), Haslanger
patent: 4474804 (1984-10-01), Das
patent: 4522949 (1985-06-01), Das
patent: 4536513 (1985-08-01), Das
patent: 4663336 (1987-05-01), Nakane
patent: 4663337 (1987-05-01), Das
As Belo Bioorg Chem, 04.03.81-SU278256 (23.11.87) C07C-177 C07D-261/06.
Chem Abs. SA Selects: Prostaglandins Issue 12, 1988 108:198903m. Kuz'mitskii, B. B. et al.
CA Selects: Prostaglandins, Issue 12, 1988, 108:204363d, Lakhvich, F. A. et al.

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