7-Oxabicycloheptane substituted thio prostaglandin analogs usefu

Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific... – Bacterium or component thereof or substance produced by said...

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Details

549463, C07D30700, A61K 3134, A61K 31557

Patent

active

044748035

ABSTRACT:
7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl or alkali metal, R.sup.1 is lower alkyl, arylalkyl, aryl, cycloalkyl or cycloalkylalkyl. A is --CH.dbd.CH or --(CH.sub.2).sub.2, n is 1 to 4, n' is 0 to 2 and m is 1 to 8, and including all stereoisomers thereof.
The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

REFERENCES:
patent: 4143054 (1979-03-01), Sprague
patent: 4187236 (1980-02-01), Sprague
patent: 4220594 (1980-09-01), Sprague
patent: 4228180 (1980-10-01), Sprague
patent: 4254044 (1981-03-01), Sprague

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