Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific... – Bacterium or component thereof or substance produced by said...
Patent
1983-03-14
1984-10-02
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Nonspecific immunoeffector, per se ; or nonspecific...
Bacterium or component thereof or substance produced by said...
549463, C07D30700, A61K 3134, A61K 31557
Patent
active
044748035
ABSTRACT:
7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl or alkali metal, R.sup.1 is lower alkyl, arylalkyl, aryl, cycloalkyl or cycloalkylalkyl. A is --CH.dbd.CH or --(CH.sub.2).sub.2, n is 1 to 4, n' is 0 to 2 and m is 1 to 8, and including all stereoisomers thereof.
The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
REFERENCES:
patent: 4143054 (1979-03-01), Sprague
patent: 4187236 (1980-02-01), Sprague
patent: 4220594 (1980-09-01), Sprague
patent: 4228180 (1980-10-01), Sprague
patent: 4254044 (1981-03-01), Sprague
Hall Steven E.
Haslanger Martin F.
Dentz Bernard I.
E. R. Squibb & Sons Inc.
Jiles Henry R.
Levinson Lawrence S.
Rodney Burton
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