7-oxabicycloheptane substituted thio prostaglandin analogs usefu

Details 7-oxabicycloheptane substituted thio prostaglandin analogs usefu 7-oxabicycloheptane substituted thio prostaglandin analogs usefu

1985-04-22

1986-08-19

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549463, A61K 31557, A61K 3134, C07D30700

Patent

active

046070494

ABSTRACT:
7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl, alkali metal, or a polyhydroxylamine salt, R.sup.1 is hydrogen, lower alkyl, arylalkyl, aryl, cycloalkyl or cycloalkylalkyl, R.sup.2 is hydrogen or lower alkyl, A is --CH.dbd.CH-- or --(CH.sub.2).sub.2, n is 1 to 4, n' is 0, 1 or 2, q is 1 to 10 and m is 0 to 8, and including all stereoisomers thereof.
The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease, and as such are useful in inhibiting platelet aggregation.

REFERENCES:
patent: 4143054 (1979-03-01), Sprague
patent: 4187236 (1980-02-01), Sprague
patent: 4220594 (1980-09-01), Sprague
patent: 4228180 (1980-10-01), Sprague
patent: 4254044 (1981-03-01), Sprague
patent: 4456616 (1984-06-01), Haslanger
patent: 4474803 (1984-10-01), Hall

Affiliated with

Also associated with

Rating

7-oxabicycloheptane substituted thio prostaglandin analogs usefu does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 7-oxabicycloheptane substituted thio prostaglandin analogs usefu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 7-oxabicycloheptane substituted thio prostaglandin analogs usefu will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-394207